One-pot synthesis of pharmacologically active secondary and tertiary 1-(3,3-diarylpropyl)amines via rhodium-catalysed hydroaminomethylation of 1,1-diarylethenes

Abstract

Pharmacologically active secondary and tertiary 1-(3,3-diarylpropyl)amines 1 are prepared in high yields and chemoselectivity by the reaction of 1,1-diarylethenes 4, primary or secondary amines 5, carbon monoxide and hydrogen in presence of [Rh(cod)Cl] 2 PBu 3 as catalyst via a one-pot hydroformylation - amine condensation - reduction sequence.