On the significance of Surfactant Protein-A within the human lungs

Mahdi Abdullah,Ekkehard Vollmer,Florian Stellmacher,Torsten Goldmann,Dagmar S Lang,Holger Schultz,Daniel Kähler

doi:10.1186/1746-1596-4-8

Mahdi Abdullah, Ekkehard Vollmer + Show 5 more

Open Access

https://doi.org/10.1186/1746-1596-4-8

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Abstract

Surfactant Protein-A (SP-A) is the most prominent among four proteins in the pulmonary surfactant-system. SP-A is expressed by alveolar epithelial cells type II as well as by a portion of non small cell lung carcinomas (NSCLC).The expression of SP-A is complexly regulated on the transcriptional and the chromosomal level. SP-A is a major player in the pulmonary cytokine-network and moreover has been described to act in the pulmonary host defense.By the use of cell culture or animal models the functional properties have been repeatedly shown in many aspects, often bearing surprising properties which strongly indicate the physiological importance of SP-A. To date SP-A is recognized as a molecule essential for pulmonary development, structure and function. An upcoming number of reports deals with the role of SP-A for pulmonary pathology. This article gives an overview about the state of knowledge on SP-A focused in applications for human pulmonary disorders and points out the importance for pathology-orientated research approaches using immunohistochemistry or in situ hybridization as promising methods to further elucidate the role of this molecule in adult lung diseases.

Highlights

Surfactant The role of the surfactant system for the development of the human lung is known to be essential. Since it is synthesized by humans starting in the 28th week of pregnancy and reaching functional levels in the 34th week, surfactantsubstitution-therapy is a fundamental part of the treatment of premature babies suffering from Infant Respiratory Distress Syndrome (IRDS)[1]
Phylogenetic analyses revealed that an ancestor proto-SPA gene was diverged into SP-A1 and a second gene which subsequently emerged to SP-A2 and the Surfactant Protein-A (SP-A) pseudogene [3]
The studies concerning the possible role of surfactantdefects in pulmonary diseases of adults have been performed mainly in different cell culture or animal models hardly analyzing adult human lung tissue

Summary

Introduction

Surfactant The role of the surfactant system for the development of the human lung is known to be essential. The central role of the surfactant system for maintaining pulmonary function has been repeatedly shown by the use of cell culture or animal models [2]. SP-A: biochemical properties and genetic organization SP-A is the major surfactant apoprotein exhibiting complex interactions and participation in processes fundamental for pulmonary structure and function with its expression restricted to alveolar epithelial cells type II.

Results

Conclusion