Expression of hypoxia inducible factor-1α, hypoxia inducible factor-2α and vascular endothelial growth factor in metastatic lung cancer and clinical significance

Abstract

Objective To discuss the expression patterns of hypoxia inducible factor(HIF)-1α, HIF- 2α and vascular endothelial growth factor(VEGF)in metastatic lung cancer tissues. Methods The immunohistochemical streptavid-in- peroxidase(SP) method was applied to detect the expression of HIF-1α, HIF- 2α and VEGF in 93 cases of surgicall resected metastatic lung cancer, and 57 cases of primary non- small- cell lung carcinoma(NSCLC)as blank control group. Results HIF-1α, HIF-2α and VEGF proteins were expressed in 72 cases of metastatic lung cancer and 58 cases of primary NSCLC with the positive rate being 77.4%, 62.3% and 74.2% respectively(P 0.05). Conclusion HIF-1α, HIF-2α and VEGF expression in lung metastases is increased, and HIF-1α expression was positively correlated with VEGF expression. Key words: Metastatic lung cancer; Hypoxia inducible factor-1α; Hypoxia inducible factor-2α; Vascular endothelial growth factor