Abstract
Objective To evaluate the prognostic value of surfactant protein A (SP-A) in nonsmall-cell lung carcinoma (NSCLC).Methods We retrospectively reviewed the pathological results of 130 surgically resected NSCLC patients,who were followed up.The samples were divided into groups according to chemotherapy status.SP-A expression level was correlated with clinicopathological characteristics.Overall survival was estimated using Kaplan-Meier method.Results SP-A positive rate was 67.7％ (88/130).Multivariate logistic regression analysis revealed that SP-A expression was significantly reduced in heavy smokers.Univariate and multivariable Cox regression analysis demonstrated that only SP-A was the independent variable affecting survival in chemotherapy group.Positive SP-A predicted longer survival (Logrank test,P ＜ 0.01).Conclusion SP-A is a potential biomarker for predicting the effectiveness of platinum-based chemotherapy in NSCLC. Key words: Surfactant protein A; Biomarker; Non-small-cell lung carcinoma
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