Abstract
In Escherichia coli B acquisition of 5-fluorouracil-induced resistance to ultraviolet irradiation appears together with incorporation of the analogue into messenger ribonucleic acid, and accumulation of this ribonucleic acid fraction. Upon removal of the analogue, rapid turnover of the 5-fluorouracil-containing messenger ribonucleic acid occurs and loss of resistance results. The postulate that accumulation of messenger ribonucleic acid may be involved in the acquisition of resistance to ultraviolet light, is supported by experiments in which bacteria were subjected to a nutritional shift from rich to minimal medium or pre-incubated with chloramphenicol prior to irradiation. Analysis of deoxyribonucleic acid hydrolysates of irradiated control and 5-fluorouracil-grown bacteria show that the analogue-induced resistance to ultraviolet light is not accompanied by a corresponding decrease in thymine-dimer formation.
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