Abstract
Abstract It is usually assumed that the phenomenon of anaphylaxis depends on the presence of soluble protein and that such proteins as horse serum, when made insoluble by heat, are deprived of their anaphylactic toxicity. Nevertheless, there is little doubt that protein heated to the boiling point acts as antigen in precipitation as well as in complement fixation reactions and produces local inflammation in animals sensitized with it (1). These observations which indicate that anaphylaxis and precipitation are independent phenomena (Pick and Yamanouchi (2)) suggested a study of anaphylaxis produced by heated serum. The heated antigen has been used for sensitization, since in earlier studies due attention has not been paid to the possibility that heated serum may effectively sensitize an animal to heated antigen. The investigations of Besredka (3), Rosenau and Anderson (4), Doerr and Russ (5), Kraus and Volk (6), Arthus (7), Uhlenhuth and Haendel (8) have shown that the sensitizing property of serum resists heat while its toxicity, it appears, is readily destroyed when it is heated to about 90°C.
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