Abstract

Abstract : The coccidioidin skin test and serologic reactions in immunized and nonimmunized monkeys are described. Experimental vaccines included killed intact cells and cell fraction antigens. Serologic tests included tube precipitin, two different agar gel immunodiffusion techniques, and two similar complement fixation (CF) tests. Skin and serologic activity was determined also in animals after aerosol infection. Both classes of reactions were greater in infected than in noninfected animals. However, the serologic response of monkeys to the disease differed in several aspects from that reported for man. Tube precipitin reaction was sporadic and where recorded tended to persist. Complement fixation reactions in infected monkeys were most nearly similar to those reported for man except that the monkey response generally was greater. Positive CF and agar gel immunodiffusion reactions were recorded in some animals early in the disease. Both types of argar gel immunodiffusion reactions paralleled the CF reactions, and they may all be tests for the same antibody. The value of these tests in immunologic studies in vivo with Coccidioides immitis is discussed.

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