Abstract
CATARACTS in rats made diabetic by pancreatectomy were observed by Foglia and Cramer 1 in 1944, and in the same year Bailey, Bailey, and Leech 2 reported cataracts in rats made diabetic with alloxan. Since these earlier studies, many investigators have obtained cataracts in diabetic rats. Most workers have pointed out that high blood sugar levels are imperative for cataract formation. This has been stressed in the recent publications of Sterling and Day 3 and Patterson. 4 By altering experimental diets, mainly by reducing the carbohydrate content, Charalampous and Hegsted 5 and Rodriguez and Krehl 6 have prevented cataract formation or delayed its onset in the diabetic rat. Kok-van Alphen 7 found that if the diabetes in the rat was controlled with insulin, cataract failed to develop. The work cited demonstrates that cataract occurs either because of failure of the lens to metabolize glucose or because the high aqueous sugar
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