Octahedral copper(II) carboxylate complex: synthesis, structural description, DNA-binding and anti-bacterial studies

Abstract

Self-assembly of CuSO4, para-methyl-2-phenyl acetate and 1,10-phenanthroline afforded good-quality crystalline complex in quantitative yield. The complex was characterized by FTIR and UV-visible spectroscopy, electrochemistry, and powder and single-crystal XRD studies. Its structure was found to possess axially elongated octahedral symmetry with CuO4N2 chromophore. Its purity was assessed by powder XRD spectrum. Absorption study yielded a broad band corresponding to 2Eg→2T2 g transition. Electrochemical solution study indicated diffusion-controlled irreversible electron transfer process corresponding to Cu(II)/Cu(I) redox couple with diffusion coefficient = 7.89(±0.1)×10−9 cm2s−1. Results of spectroscopic techniques support each other. Complex exhibited excellent DNA-binding ability through UV-visible spectroscopy and cyclic voltammetry yielding Kb values 1.399 × 104 M−1 and 5.81 × 103 M−1, respectively. The complex exhibited significant activity against bacterial strains Escherichia coli, Micrococcus luteus and Staphylococcus aureus and good activity against Bacillus subtilis. These preliminary studies impart good biological relevance on the synthesized complex.