Synthesis, characterization and antimicrobial activity of zinc(II) ibuprofen complexes with nitrogen-based ligands

Abstract

AbstractMetal carboxylate complexes possess different carboxylate coordination modes, e.g. monodentate, bidentate, and bridging bidentate. Five Zn(II) complexes were prepared and characterized in order to examine their coordination modes in addition to their biological activity. The syntheses were started by preparation of [Zn(ibup)2(H2O)2] (1). Then, different nitrogen-donor ligands reacted with 1 to produce [Zn(ibup)2(2-ampy)2] (2), [Zn(ibup)(2-ammethylpy)] (3), [Zn(ibup)(2,2′-bipy)] (4), and [Zn2(ibup)4(2-methylampy)2] (5) (ibup = ibuprofen, 2-ampy = 2-aminopyridine, 2-ammethylpy = 2-aminomethylpyridine, 2,2′-bipy = 2,2′-bipyridine, 2-methylampy = 2-(methylamino)pyridine). IR, 1H NMR, 13C{1H}-NMR and UV–vis spectroscopies were used for characterization. The crystal structures of 2 and 5 were determined by single-crystal X-ray diffraction. Investigation of in vitro antibacterial activities for the complexes against Gram-positive (Micrococcus luteus, Staphylococcus aureus and Bacillus subtilis) and Gram-...