Abstract
The liver of the parrotfish Ypsiscarus ovifrons sometimes causes severe muscle pain, paralysis and dyspnea when ingested by humans. Individual livers, ovaries and digestive tracts and their contents were examined for lethal potency in mice. They were all toxic, except for livers obtained from April to June. Lethal potency ranged from 0.25 to 5.0 MU/g tissue. Livers were extracted with acidic aqueous ethanol and the extracts purified by charcoal treatment, gel filtration and partition and reversed phase column chromatography. Both the crude and partially purified toxin showed chemical and/or pharmacological properties different from those of tetrodotoxin or paralytic shellfish poisons.
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