Observation on the effects of different doses of oxaliplatin chemotherapy regimen for treatment of colorectal cancer and the adverse reactions in the nervous system

Abstract

Objective To investigate the effects of different doses of oxaliplatin (L-OHP) chemotherapy regimen for treatment of colorectal cancer and its influence on the adverse reactions in the nervous system. Methods A total of 92 cases of colorectal cancer patients in Wuhan Wuchang Hospital from August 2013 to April 2016 were selected as the research objects, which were randomly divided into the observation group (46 cases) and the control group (46 cases) according to the random lottery envelopes. All the patients were given FOLFOX chemotherapy. The observation group was treated with small dose L-OHP chemotherapy (60 mg/m2), the control group was treated with routine dose of L-OHP chemotherapy (120 mg/m2), and the efficacies were evaluated after 3 cycles. Results All the patients completed chemotherapy. The observation group included 26 cases of complete remission (CR), 11 cases of partial remission (PR), 5 cases of stable disease (SD), 4 cases of progression of disease (PD). The control group included 28 cases of CR, 10 cases of PR, 3 cases of SD, 5 cases of PD. Overall response rate (ORR) in the observation group and the control group were 80.4% (37/46) and 82.6% (38/46) respectively, and there was no significant difference between the two groups (χ2= 0.072, P > 0.05). Nervous system adverse reactions included 6 cases of grade Ⅰ, 3 cases of grade Ⅱ, 1 case of grade Ⅲ in the observation group, and 12 cases of grade Ⅰ, 6 cases of grade Ⅱ, 4 cases of grade Ⅲ in the control group. The incidence rate in the observation group was lower than that in the control group [21.7% (10/46) vs. 47.8% (22/46), χ2= 6.900, P < 0.05]. Up to November 2017, PD and overall survival time in the observation group were longer than those in the control group [(19±4) months vs. (16±4) months, t= 4.314, P < 0.05; (24±4) months vs. (20±5) months, t= 4.170, P < 0.05]. Conclusion The low dose L-OHP chemotherapy regimen has a favorable effect in patients with colorectal cancer, and it can reduce the adverse reactions in the nervous system and prolong the survival time of patients. Key words: Intestinal neoplasms; Drug therapy, combination; Oxaliplati; Drug toxicity