Observation on the Effect of Non-Invasive Ventilator Combined with Conventional Therapy in the Treatment of Chronic Obstructive Pulmonary Disease Complicated with Respiratory Failure

Abstract

Objective: To explore the clinical effect of a non-invasive ventilator combined with conventional therapy in the treatment of patients with chronic obstructive pulmonary disease (COPD) combined with respiratory failure. Methods: 68 patients with COPD combined with respiratory failure treated in our hospital from September 2021 to October 2023 were selected as the research subjects. Using the random number table method, they were divided into a control group and an experimental group of 34 cases each. The control group received conventional symptomatic treatment, and the experimental group received non-invasive ventilator treatment based on the control group. The clinical effects, blood gas indicators (partial pressure of carbon dioxide (PaCO2), partial pressure of oxygen (PaO2), arterial oxygen saturation (SaO2)), lung function (forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), 6 min walking distance), complications, and inflammatory factor levels (c-reactive protein (CRP), interleukin-6 (IL-6), neutrophil-to- lymphocyte ratio (NLR)) of the two groups of patients were observed. Results: (1) The clinical efficacy of the patients in the experimental group (33/97.06%) was more significant as compared with the control group (25/73.53%) (P < 0.05); (2) After treatment, the clinical efficacy of the two groups of patients in terms of FEV1, FEV1 /FVC, 6-minute walking distance, PaO2 and SaO2 all increased in the experimental group as compared to that of the control group (P < 0.05); (3) After treatment, the PaCO2, CRP, IL-6, and NLR of the two groups of patients decreased, and the decrease in the experimental group was higher than that of the control group (P < 0.05); (4) The patients’ complication rate in the experimental group (2/5.88%) was lower as compared to that of the control group (9/26.46%) (P < 0.05). Conclusion: Non-invasive ventilators combined with conventional therapy achieved good clinical results in treating patients with COPD and respiratory failure.