Observation of the effect of oxymatrine combined with interferon alpha-2b in the treatment of patients with chronic hepatitis B

Abstract

Objective To investigate the clinical value of oxymatrine combined with interferon alpha-2b in the treatment of chronic hepatitis B. Methods From January 2014 to January 2017, Ninety patients with chronic hepatitis B in the Third People's Hospital of Linfen were divided into observation group and control group according to the random number table method, with 45 cases in each group.The control group was treated with recombinant human interferon alpha-2b, intramuscular injection of 5 million IU, 1 time/d, and on the basis of the control group, the observation group was treated with oxymatrine injection 500 mg+ 0.9% sodium chloride injection 250mL, intravenous infusion of normal saline, 1 time/d, the treatment cycle was 6 months.The changes of liver function, HBV-DNA negative rate and liver fibrosis indicators were compared between the two groups before and after treatment. Results After treatment, the liver function indicators of the observation group and the control group[ALT(45.2±8.3)IU/L, (68.4±9.5)IU/L; AST(42.6±7.2)IU/L, (63.7±9.3)IU/L]were significantly decreased, which of the observation group were significantly lower than those of the control group, the differences were statistically significant (t=11.678, 10.186, all P<0.05). The negative rate of HBV-DNA in the observation group(82.2%) was significantly higher than that in the control group(60.0%), the difference was statistically significant(χ2=5.409, P<0.05). After treatment, the levels of Ⅳ-C[(57.7±10.6)ng/L, (132.2±47.6)ng/L], LN[(103.1±33.1)ng/L, (162.5±57.9)ng/L]and HA[(158.7±59.2)ng/L, (263.4±97.9)ng/L]of the observation group and the control group were significantly decreased, which of the observation group were significantly lower than those of the control group, the differences were statistically significant (t=9.899, 5.971, 5.856, all P<0.05). Conclusion Oxymatrine injection combined with interferon alpha-2b in the treatment of chronic hepatitis B can significantly improve liver function, improve the negative rate of virus and liver fibrosis. Key words: Hepatitis B; Interferon Alfa-2b; Oxymatrine