Obesity hypoventilation syndrome in obstructive sleep apnea patients in the United Arab Emirates: a retrospective cross-sectional study

Abstract

ObjectivesTo estimate the frequency of symptoms of obesity hypoventilation syndrome (OHS) in patients with obstructive sleep apnoea (OSA) and to evaluate comorbidities associated with OHS.DesignRetrospective study based on patients' medical records and on further sleep tests performed in the study centre during the inclusion visit.SettingRespiratory Care Unit and Sleep Disorder Centre of the Zayed Military Hospital United Arab Emirates.ParticipantsAll patients referred to the study centre for a suspicion of sleep-disordered breathing.Main outcome measuresPrevalence of OSA and OSA + OHS and comorbidities in patients with OSA and OHS.ResultsA total of 212 adult patients participated in the study. Of these, 107 patients (50.5% [43.8–57.1% CI 95%]) fulfilled diagnostic criteria for OSA, and the majority were men (79.4%). Among patients with OSA, 18 patients (16.8% [10.8–25.1% CI 95%]) fulfilled diagnostic criteria for OHS. In this group, women were more frequently affected than men (31.8% [7/22] vs. 12.9% [11/85], respectively; p = 0.03) and tended to be older than affected men, with a mean age of 55 ± 10.6 years versus 46 ± 13 for men. After adjustment for gender, OHS was significantly associated with hypertension (OR = 3.5; p = 0.03), diabetes mellitus (OR = 4.6; p = 0.02), ischaemic heart disease (OR = 5.1; p = 0.04) and pulmonary hypertension (OR = 16.1; p = 0.001).ConclusionOHS is a common condition in obese patients in the UAE and is associated with an increased risk of cardiovascular comorbidities and diabetes.