Abstract
Pre-clinical SCS studies have previously demonstrated that neural activity, and in turn, perception of pain can be robustly modulated via the stimulation of different neuronal targets (e.g., dorsal Horn, dorsal column).1,2 Stimulation of multiple simultaneous targets via the dual use of sub- and supra-perception-based SCS modalities (i.e., combination therapy) may therefore be able to enhance pain relief outcomes. Positive outcomes when using combination therapy in SCS-implanted patients have now been recently reported.3,4 Here, we will report long-term clinical outcomes up to 2-years from a prospective, randomized controlled trial (RCT) that evaluated the effectiveness of SCS using sub- and supra-perception modalities as a combination therapy for chronic pain.
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