Abstract
AbstractBackgroundResident memory T (TRM) cells and immunosuppressive Foxp3‐expressing regulatory TRM (regTRM) cells are present in healthy, non‐inflamed and inflamed human skin. Both types of cells are found in both the epidermis and dermis with the dermis being much thicker than the epidermis. However, it is unclear if TRM and regTRM cells differ between reticular dermal layers in terms of number, function or characteristics.MethodsThis study examined numerical, phenotypic and functional differences in TRM and regTRM cells between the upper and lower reticular dermis in healthy, non‐inflamed human skin using flow cytometry.ResultsThe phenotype and cytokine expressions of both types of cells were similar between reticular dermal layers. However, the cell count of both TRM and regTRM cells was significantly higher in the upper reticular dermis than in the lower reticular dermis.ConclusionsTRM and regTRM cells are phenotypically and functionally identical between reticular dermal layers. However, both types of cells are more abundant in the upper reticular dermis.
Published Version
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