Novi lekovi - značaj slučajnog otkrića

Abstract

The key elements of serendipity are luck and contemplation. The discovery process includes the recognition of the finding potential based on knowledge and experience. Serendipitous discoveries are common in biomedical sciences. A significant number of pharmaceuticals is the result of serendipity. Drugs belonging to antimicrobial agents, central nervous system active substances as well as antitumor agents, gained great benefit from serendipity conditions. Besides in the traditional, irrational approach in the drug design, serendipitous discoveries have also played role in modern strategies, such as the drug repositioning and the development of multi-target antitumor agents. Serendipitous drugs discoveries can be classified as laboratory or clinical ones, depending on the drug development stage and the circumstances under which the combination of unforeseen events, the knowledge and skills of the researcher occurred. The discovery of a new drug is impossible without outstanding science as well as the dedication, freedom, and open-mindedness of the researcher to act, think, take a risk, and challenge dogmas.