Computational approaches for drug design and discovery: An overview

Abstract

The process of drug discovery is very complex and requires an interdisciplinary effort to design effective and commercially feasible drugs. The objective of drug design is to find a chemical compound that can fit to a specific cavity on a protein target both geometrically and chemically. After passing the animal tests and human clinical trials, this compound becomes a drug available to patients. The conventional drug design methods include random screening of chemicals found in nature or synthesized in laboratories. The problems with this method are long design cycle and high cost. Modern approach including structure-based drug design with the help of informatic technologies and computational methods has speeded up the drug discovery process in an efficient manner. Remarkable progress has been made during the past five years in almost all the areas concerned with drug design and discovery. An improved generation of softwares with easy operation and superior computational tools to generate chemically stable and worthy compounds with refinement capability has been developed. These tools can tap into cheminformation to shorten the cycle of drug discovery, and thus make drug discovery more cost-effective. A complete overview of drug discovery process with comparison of conventional approaches of drug discovery is discussed here. Special emphasis is given on computational approaches for drug discovery along with salient features and applications of the softwares used in de novo drug designing. How to Cite this Article Pubmed Style Baldi A. Approaches for Drug Design and Discovery: An SRP. 2010; 1(1): 99-105. doi:10.4103/0975-8453.59519 Web Style Baldi A. Approaches for Drug Design and Discovery: An http://www.sysrevpharm.org/?mno=302644637 [Access: March 28, 2021]. doi:10.4103/0975-8453.59519 AMA (American Medical Association) Style Baldi A. Approaches for Drug Design and Discovery: An SRP. 2010; 1(1): 99-105. doi:10.4103/0975-8453.59519 Vancouver/ICMJE Style Baldi A. Approaches for Drug Design and Discovery: An SRP. (2010), [cited March 28, 2021]; 1(1): 99-105. doi:10.4103/0975-8453.59519 Harvard Style Baldi A (2010) Approaches for Drug Design and Discovery: An SRP, 1 (1), 99-105. doi:10.4103/0975-8453.59519 Turabian Style Baldi A. 2010. Approaches for Drug Design and Discovery: An Systematic Reviews in Pharmacy, 1 (1), 99-105. doi:10.4103/0975-8453.59519 Chicago Style Baldi A. Computational Approaches for Drug Design and Discovery: An Overview. Systematic Reviews in Pharmacy 1 (2010), 99-105. doi:10.4103/0975-8453.59519 MLA (The Modern Language Association) Style Baldi A. Computational Approaches for Drug Design and Discovery: An Overview. Systematic Reviews in Pharmacy 1.1 (2010), 99-105. Print. doi:10.4103/0975-8453.59519 APA (American Psychological Association) Style Baldi A (2010) Approaches for Drug Design and Discovery: An Systematic Reviews in Pharmacy, 1 (1), 99-105. doi:10.4103/0975-8453.59519