Abstract
Selective antagonists for ATP-mediated P 2-purinoceptors have recently become available and have proved useful tools in the study of ATP in synaptic transmission. Takeshi Katsuragi and Tatsuo Furukawa review the data on novel purinoceptor antagonists and discuss the implications of the observations that clonidine and the ATP analogs, arylazidoaminopropionyl ATP and α,β-methylene ATP, produce selective antagonism for P 1- and P 2-purinoceptors, respectively. Experiments utilizing these antagonists support the hypothesis that endogenous ATP and noradrenaline exist as co-transmitters in the neuromuscular junction of rodent vas deferens.
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