Abstract
Aim: To synthesizeand explore the therapeutic potential of amodiaquine analogues. Methodology: New promising analogues weresynthesized by nucleophilic substitution at the 4-amino position and were characterized using 1H NMR, 13C NMRand FT-IR spectroscopic techniques. Results: Antibacterial and cytotoxic screening revealed the high potency of these compounds; analogue AS1 had an34.3±0.18mm zone of inhibition against Pseudomonas aeruginosa. Excellent activity against fungal strains, that is, Candida albicans (39.6±0.23mm) was shown by analogue AS2. Analogue AS1 had an IC50=4.2μg/ml against the HeLa cell line (cervical cancer) and binding energy against 5GWK (-8.32688kcal/mol), 1PFK (-6.4780kcal/mol) and 1TUP (-6.5279kcal/mol) in the docking study. Conclusion: The obtained results reveal that these analogues exhibit potent antimicrobial and cytotoxic potential.
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