Novel acrylate copolymer based on 4-(2-bromo-3-(4-bromophenyl)-3-oxo prop-1-enyl) phenyl acrylate: Synthesis, characterization, biological and drug releasing studies

Abstract

Novel copolymer poly(DBA-co-GMA) and poly(DBA-co-MA) was synthesized by utilizing synthesized 4-(2-bromo-3-(4-bromophenyl)-3-oxo prop-1-enyl) phenyl acrylate (DBA), Glycidyl methacrylate and Methacrylic acid. Solution polymerization technique is used for the above said polymer preparation, 1H NMR, FT-IR and UV spectrophotometer confirms the formation of copolymer. The presence of functional groups confirms by the FT-IR spectrum. The UV–visible spectrum shows two absorption peak around 250 and 340 nm. The polymerized proton peak which is present around 1 to 1.5 ppm in the 1H NMR confirms the formation of the product. Synthesized polymer having weight average molecular weight around 8000 g/mol was confirmed by gel permeation chromatography technique. Polymers showed two stage decomposition patterns when subjected to thermal treatment. All polymeric compounds are highly active on both gram positive and gram negative bacteria. Antimicrobial activity is high for the tested bacteria especially for E. coli (3.91 µg/mL). The drug releasing behavior of the copolymer is studied by the UV–visible spectroscopic technique and the drug releasing behavior of the polymer was found that it follows Fickian model.