Abstract
Background: The objective of this study was to investigate the correlation between norovirus genogroup and severity of acute diarrhea in pediatric patients at the Dr. Soetomo Hospital, Surabaya, Indonesia. Methods: This cross-sectional study involved 31 participants aged 1-60 months admitted to the hospital with acute diarrhea from April 2012 to March 2013. Norovirus genogroups (GI and II) were identified from patient stool using reverse transcription polymerase chain reaction (RT-PCR). Severity was measured using the Ruuska and Vesikari scoring system. Results: In total, 91 stool samples were obtained, of which 31 (19%) were norovirus positive. Norovirus GI was found in one sample with mild diarrhea. Norovirus GII was found in 30 samples (96.8%); one sample with mild diarrhea (3.3%), 20 samples with moderate diarrhea (66.7%), and nine samples with severe diarrhea (30%). Conclusion: Norovirus GII was the most prevalent cause of acute diarrhea and 30% of the cases manifested as severe diarrhea.
Highlights
Diarrhea is considered the second-leading cause of death in pediatric patients under the age of five with a worldwide annual mortality of 525,000 children
This paper aimed to examine the correlation between norovirus genogroup and acute diarrhea severity in pediatric patients aged 1–60 months in the Dr Soetomo General Hospital, Surabaya, Indonesia
Norovirus has been reported to be the main cause of acute diarrhea worldwide after rotavirus in all age groups of pediatric patients both in developed and developing countries[2,3]
Summary
Diarrhea is considered the second-leading cause of death in pediatric patients under the age of five with a worldwide annual mortality of 525,000 children. Viruses from the genus Norovirus from the family Caliciviridae are the second-leading cause of acute diarrhea after rotavirus in all age groups of pediatric patients[2,3,4]. The objective of this study was to investigate the correlation between norovirus genogroup and severity of acute diarrhea in pediatric patients at the Dr Soetomo Hospital, Surabaya, Indonesia. Norovirus genogroups (GI and II) were identified from patient stool using reverse transcription polymerase chain reaction (RT-PCR). Conclusion: Norovirus GII was the most prevalent cause of acute diarrhea and 30% of the cases manifested as severe diarrhea
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