Normalization of the immune system of large cattle with the help of “Immunopheron” and “Ribotan” medicines

Abstract

This article presents the results of studying the effect of immunostimulants “Immunoferon” and “Ribotan” on the indices of specific and non-specific resistance of calves. To this end, according to the principle of analogues, 3 groups of calves were formed, with 5 animals each. Calves of the third group served as a control. In the blood of calves, the content of immunoglobulins A, M, G was determined on the analyzer “Uniplan”. The number of T-lymphocytes in the blood was determined by the method of spontaneous rosette formation with erythrocytes of a ram, B-lymphocytes - by the method of complementary rosette formation using standard rabbit hemolysin and as a complement - fresh serum of cows. The bactericidal activity of the blood serum (BASK) was determined by O.V. Smirnova and TA. Kuzminoy, lysozyme activity of blood serum (LASK) - according to KA. Kagramanova and Z.V. Ermolieva, phagocytic index and number (FH and FI) - according to V.S. Gostevu. Experiments showed that the calves of the experimental groups showed an increase in serum levels of immunoglobulin A, M and G, as well as bactericidal and lysozyme activity of blood serum, a phagocytic number and an index. The relative and absolute levels of B-lymphocytes and T-lymphocytes were also significantly higher in the calves of the test groups than in the control group. And the most significant changes were noted with the use of the drug “Immunoferon”.