Abstract
Intestinal metaplasia has been widely considered as a precursor of gastric cancer. As a result, early detection and accurate diagnosis will have important clinical significance. Therefore, nonlinear optical microscopy using two-photon excited fluorescence combined with second harmonic generation was used for investigating gastric mucosal intestinal metaplasia in this work. The imaging results showed that this microscope has the ability to directly identify this lesion from normal tissues in the absence of labels, and to further differentiate the subtyping of intestinal metaplasia. Furthermore, nuclear areas from normal gastric mucosa and intestinal metaplasia subtypes were measured, respectively, to show the cell changes while gastric mucosa developed from normal to intestinal metaplasia. This study may provide an approach for further researching these diseases in the future, and highlights the potential of nonlinear optical microscopy as a diagnostic tool for label-free identification of gastric intestinal metaplasia.
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