Abstract
Cell lines derived from C3H mouse embryos are described. Untransformed MO-cells were found susceptible to transformation by Kirsten MSV. Two types of transformed cell lines were isolated. MO-P-cells produced infectious MSV and contained extracellular C-type particles. MO4-cells did not release infectious focus forming virus; however, upon superinfection with murine leukemia viruses (MLV), infectious MSV was released. Not superinfected MO4-cells contained multiple intracisternal A-type particles. In this respect these cells differ from the MSV genome-carrying NP-cells (1) which do not produce particles nor viral antigen, and from S+L−-cells (2) which release extracellular, non-infectious C-type particles.
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