Abstract
Non-coding ribonucleic acids were thought to be non-functional transcription products decades ago. But recently they have been found to play an essential role in programmed regulation in a variety of diseases, including cancer. They include micro ribonucleic acids and their upstream long non-coding ribonucleic acids and circular ribonucleic acids. Long non-coding ribonucleic acids or circular ribonucleic acids can form a regulatory network through sponging micro ribonucleic acids. The network regulates biological functions of various tumors such as proliferation, invasion and drug resistance. In addition, other non-coding ribonucleic acids such as piwi-interacting ribonucleic acids, transfer ribonucleic acids, ribosomal ribonucleic acids, small nuclear ribonucleic acids and small nucleolar ribonucleic acids can also act as regulators of the biological characteristics of tumor cells. Ferroptosis is a programmed cell death, which is distinct from the classical caspase splicing and has received increasing attention in recent years with regard to the tumorigenesis and treatment of cancer. Interestingly, non-coding ribonucleic acids have been found to regulate ferroptosis in tumors and to maintain the biological function of tumor cells. Herein, we summarize the related research and emphasize that the regulation of ferroptosis in tumor cells by non-coding ribonucleic acids may provide a basis for future targeted cancer therapy.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.