Abstract

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Highlights

  • Emerging evidence suggests that at least one essential function of noncoding RNAs (ncRNAs) is gene expression regulation, through, for example, ribonucleic acids (RNAs) interference, gene silencing, DNA demethylation, chromatin remodeling, and gene activation[2,6,7,8,9]

  • Genetics and Molecular Neurobiology Branch, Division of Basic Neuroscience and Behavioral Research, National Institute on Drug Abuse, National Institutes of Health, U.S Department of Health and Human Services

  • Many noncoding RNAs (ncRNAs) are integrated into large complexes with proteins and likely other ribonucleic acids (RNAs) that lead to diverse biological reactions

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Summary

Introduction

Emerging evidence suggests that at least one essential function of ncRNA is gene expression regulation, through, for example, RNA interference, gene silencing, DNA demethylation, chromatin remodeling, and gene activation[2,6,7,8,9]. HAR1 is part of the ncRNA gene HAR1F that is expressed in the Cajal-Retzius neurons in the developing human cortex.

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