Abstract
The toxic effects of copaiba oil-resin (ORC) and the copaiba oil-resin vaginal cream (CVC) were evaluated in subacute treatment phase, in wistar rats, which were treated orally (p.o) and intravagin...
Highlights
The copaibeiras are common trees of Latin America and Western Africa (Cascon & Gilbert, 2000; Francisco, 2005; Maciel et al 2002)
The subacute treatment with C. duckei oil-resin and cream (CVC) did not cause clinical signs of toxicity, no deaths have been reported and did not change significantly the parameters evaluated in this study
Based on the application of vaginal cream of oil-resin copaiba, this study aimed to evaluate the toxic effects of the subchronic treatment phase
Summary
The copaibeiras are common trees of Latin America and Western Africa (Cascon & Gilbert, 2000; Francisco, 2005; Maciel et al 2002). The copaiba oil is a natural product composed of a solid, non-volatile resin, formed by acids. These acids are responsible for 55 to 60% of the oil, diluted in the other part, an essential oil, compound of sesquiterpenes, which can be divided into oxygenated sesquiterpenes (alcohols) and hydrocarbons sesquiterpenes (Cascon & Gilbert, 2000; Maciel, Pinto, Veiga-Júnior, Grynberg, & Echevarria, 2002). Several microbial infections (bacterial, viral, or fungal) are reported in the literature. Organisms responsible for the infections, bacterial or fungal, acquire resistance to the administered drugs, and for this reason, a large number of antibiotics and/or chemotherapeutic agents have been developed (Koshi & Cherian, 1995)
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