Abstract
Alternative protocols for the treatment of skin lesions have been developed with the use of techniques such as photobiomodulation and phytotherapy, aiming to optimize this process. To evaluate the effectiveness of copaiba (Copaiferalangsdorffii) oil-resin and low-level laser therapy for treating cutaneous wounds, 15 Wistar rats (Rattusnorvergicus) were used, in whom five 8-mm lesions were produced. The following protocols were applied: negative control group (T1); positive control group (T2); laser therapy with AsGa (904 nm), continuous, focal mode for 10 s, dosage of 4 J/cm² (T3); copaiba oil-resin (T4); and association group (copaiba and low-level laser) (T5). The efficacy of each technique was evaluated based on macroscopic aspects of the lesion, wound healing rate, and histopathological analysis (inflammatory infiltrate and collagen expression). The Kruskal-Wallis test was used for statistical analyses (P> 0.05). Copaiba treatment showed an advantage in type III collagen expression, whereas laser therapy demonstrated an enhanced capacity for tissue regeneration. The significant advantage obtained from the association treatment is the improvement of the macroscopic aspect of the wound, with a reduction in crust formation.
Highlights
Wound healing is a dynamic process that is divided into three distinct phases: inflammatory, proliferative, and remodeling (MAVER et al, 2015)
Excessive crust formation in ulcers treated with copaiba oil-resin resulted in inferior wound contraction, delaying the healing process
This tendency remained during the study, showing T1 as most effective for area reduction, as seen by day 7, when the negative control exposed the minor wounds, and those treated with copaiba oil-resin, and the association group, larger ulcers, equivalent to T2, indicating the inferior ability of injury contraction (KruskalWallis test; p
Summary
Wound healing is a dynamic process that is divided into three distinct phases: inflammatory, proliferative, and remodeling (MAVER et al, 2015). The diversity of laser models creates flexible protocols that vary in power, wavelength, frequency, intensity, and dose (J/cm2) (FARIVAR; MALEKSHAHABI; SHIARI, 2014), which adapt according to the intention of the treatment. Another form of alternative therapy is herbal medicine, which, according to Ghosh and Gaba (2013), presents antimicrobial and antioxidant effects and promotes mitosis and angiogenesis. The effects of copaiba, laser, and their association on induced cutaneous wounds in Wistar rats were studied
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