Abstract
BackgroundThe regeneration of integrity and tissue homeostasis after injury is a fundamental property and involves complex biological processes fully dynamic and interconnected. Although there are medications prescribed to accelerate the process of wound healing by reducing the exaggerated inflammatory response, comes the need to search for different compounds of Amazonian biodiversity that can contribute to the acceleration of the healing process. Among these products, the copaiba oil-resin is one of the most prominent feature in this scenario, as they have been reported its medicinal properties.MethodsAiming to evaluate the anti-inflammatory and healing effect of copaiba oil-resin (Copaifera reticulata Ducke) in transfixing injury of rats’ tongues first proceeded up the copaiba oil-resin oral toxicity test in 5 male mice to stipulate the therapeutic dose which was established at 200 mg/kg/day. Then it was induced transfixing injury in a total of 15 Wistar rats. The animals were randomly divided into three groups based on the treatment: control group, dexamethasone group and copaiba oil-resin group. After 7 days of treatment, histological slides stained with hematoxylin and eosin was prepared. Immunohistochemistry for CD68 (macrophage marker) was performed and analyzed by the cell counter Image J.ResultsThe acute toxicity test showed that the oil-resin copal has low toxicity. Furthermore, copaiba oil-resin therapy modulates the inflammatory response by decreasing the chronic inflammatory infiltrate, edema and specifically the number of macrophages.ConclusionsThe results indicate the potential of the Amazon region and showed up relevant because therapy with this extract modulates the inflammatory process.
Highlights
The regeneration of integrity and tissue homeostasis after injury is a fundamental property and involves complex biological processes fully dynamic and interconnected
Oil-resin characterization The copaiba oil-resin used in this research was extracted from the species, Copaifera reticulata Ducke, and has been characterized by Guimarães-Santos et al in 2012 [8]
The dose prescribed for this study was 10% of the limit dose, i.e., the copaiba oil-resin group of animals received 200 mg/kg/day and the control animals received 200 mL/kg/day of Tween 20
Summary
The regeneration of integrity and tissue homeostasis after injury is a fundamental property and involves complex biological processes fully dynamic and interconnected. There are medications prescribed to accelerate the process of wound healing by reducing the exaggerated inflammatory response, comes the need to search for different compounds of Amazonian biodiversity that can contribute to the acceleration of the healing process. Among these products, the copaiba oil-resin is one of the most prominent feature in this scenario, as they have been reported its medicinal properties. The oil-resin, copaiba, is a natural product of the Amazon’s biodiversity more highlighted in this scenery [1, 2], mainly due to its anti-inflammatory and healing properties [2, 3]. Copaiba oil-resin is found in very popular street markets indicated treatments with injured due to their possible anti- inflammatory activity and healing [2]
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