Abstract
Nucleotide-binding oligomerization domain receptor (NLR) family pyrin domain containing protein (NLRP)3 inflammasome is a kind of macromolecular protein complex. It regulates the maturity and secretion of cytokine interleukin (IL) -1β, -18, and cysteine-aspartic protease (caspase)-1 dependented cell death (pyroptosis), through caspase -1. Its activation was strictly controlled. In recent years, many research results showed that the NLRP3 inflammasome was closely related to the occurrence, development and severity of graft versus host disease (GVHD). This article reviews literatures on NLRP3 inflammasome complex and its role in the prevention and control of GVHD. Key words: NLRP3 protein, human; Caspases; Graft vs host disease
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