Abstract
Nucleotide binding oligomerization domain (NOD)-like receptor pyrin domain containing 3 (NLRP3) inflammasome plays a vital role in innate immune responses. Activation of NLRP3 inflammasomes promotes caspase-1-mediated secretion of proinflammatory cytokines IL-1β and IL-18 and pyroptosis. Many researches demonstrate that NLRP3 inflammasome plays an important role in acute lung injury (ALI). This article reviews NLRP3 inflammasome and underlying mechanism in the onset of ALI, developing to acute respiratory distress syndrome (ARDS) and pulmonary fibrosis. Key words: Nucleotide binding oligomerization domain-like receptor pyrin domain containing 3 inflammasome; Acute lung injury; Acute respiratory distress syndrome; Pulmonary fibrosis
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: International Journal of Anesthesiology and Resuscitation
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
