Abstract
目的 探讨糖尿病合并妊娠患者脐血一氧化氮(NO)和内皮素(ET-1)水平的变化,以及脐血NO/ET-1水平与脐动脉血流阻力的关系.方法随机选择糖尿病合并妊娠(DMP)30例,妊娠期糖尿病(GDM)36例,同期选择36例正常孕妇(NP)为对照组.所有孕妇分娩后立即采集脐静脉血,分别以Griess法和放免法测定NO和ET-1含量,同时在分娩前测定脐动脉血流阻力(S/D).结果与对照组相比,DMP组NO含量显著降低,ET-1含量明显升高,脐动脉血流阻力S/D明显增加(P＜0.05).DMP组脐血NO水平与脐动脉血流阻力S/D成负相关(r=-0.688,P＜0.05),而ET-1水平与脐动脉血流阻力S/D成正相关(r=0.620,P＜0.05).GDM组和对照组之间在脐血NO和ET-1含量、脐动脉血流阻力S/D等方面差异均无统计学意义(P＞0.05).结论糖尿病合并妊娠患者脐血NO和ET-1水平异常,从而引起子宫胎盘-胎儿血流阻力增加,并最终可能导致不良妊娠结局。
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