Abstract
Chemotherapy and radiotherapy are among the traditional methods used in cancer treatment and they cause toxicity to normal cells. The purpose of the present study is to determine the possible protective role of Nigella sativa seed (2 g/kg) extract as a potent antioxidant in improving the toxicity of doxorubicin (DOX) and/or gamma radiation in albino rats. The rats were injected with DOX (2.5 mg/kg, i.p.) and/or exposed the rats to irradiation (2 Gy, whole-body) weekly, for four consecutive weeks. The antioxidant treatments were used daily via oral gavages for two weeks protection period and during the experiment (4 weeks). The DOX and/or irradiated groups recorded a severe reduction of antioxidant parameters (superoxide dismutase, catalase and reduced glutathione) as well as increased thiobarbituric acid reactive substances, and changes of liver function parameters (transaminases, alkaline phosphatase, total protein and albumin as compared with control rats. Administration of Nigella sativa seed extract to DOX and/or irradiated rats indicates significantly enhanced the oxidative stress markers and liver function parameters as compared with DOX and/or irradiated rats. In conclusion, Nigella sativa seed extract fruit extract used to decrease the bad side effects of chemotherapy and radiotherapy.
Highlights
The incidence and prevalence of cancer have been increasing in such a degree that it has become the second leading cause of death globally
In light of the previous hypothesis, the present study aims to investigate the potential hepatoprotective effects of Nigella sativa seed Fruit extract, as potent antioxidants, in their recommended antioxidant doses, against doxorubicin
The percentage of change from serum total protein and albumin in the groups treated with DOX and radiation showed a significant decrease when compared with the corresponding value of the control group
Summary
The incidence and prevalence of cancer have been increasing in such a degree that it has become the second leading cause of death globally. In 2018 World Health Organization approved that cancer is a leading cause of death in many countries, accounting for 9.6 million deaths, approximately 70% of deaths from cancer occur in low- and middle-income countries, (WHO, 2018). Liver cancer is one of the most common cancers representing a leading cause of cancer-related mortality, with an increasing incidence worldwide, being responsible for about one million deaths every year (Lee et al, 2005; Ferlay et al, 2015). Cancer is often treated with some combination of radiation therapy, surgery, chemotherapy and targeted therapy (National Cancer Institute, 2018 & WHO, 2018) Physiology and Molecular biology ) Vol 12(1 ) pp.1-14(2019)
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