Abstract
The present study examined the ability of antioxidant effects of nicotine on 1-methyl-4-phenylpyridinium ion (MPP +)-induced hydroxyl radical (·OH) formation of rat striatum. Rats were anesthetized and sodium salicylate in Ringer's solution (0.5 nmol/μl per min) was infused through a microdialysis probe to detect the generation of ·OH as reflected by non-enzymatic formation trapped as 2,3-dihydroxybenzoic acid (DHBA) in the striatum. MPP + enhanced generation of ·OH formation trapped as DHBA. However, nicotine (100 μM) significantly suppressed ·OH formation induced by MPP +. Iron (II) (2, 5 and 10 μM) increased the levels of DHBA in a concentration-dependent manner. However, in the presence of nicotine (100 μM), the effect of nicotine was suppressed. These results suggest that nicotine has a preventive effect on ·OH generation by MPP + in rat striatum.
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