New treatment modality by adoptive transfer of chimeric cells from two different MHC mismatched donors

Abstract

Background: Donor bone marrow transplantation (BMT) may promote chimerism in solid organ and composite tissue allografts. This study was designed to evaluate the rationale of immunotherapy with adoptive transfer of donor-specific cells originated from two different MHC mismatched donors and transplanted to the same recipients. Methods: Seven primary trimera were created across the MHC barrier from LBN (RT1n) (n = 7) and ACI (RT1a) (n = 7) donors to LEW (RT1l) recipients (n = 7), under a 7-day protocol of αβ-TCRmAb/CsA therapy.