Abstract
Background: Engraftment of donor-derived bone marrow cells into recipient bone marrow environment can induce hematopoietic chimerism and tolerance to antigen-matched organs in solid organ and composite tissue allograft. This study was designed to investigate the effect of intraosseous bone marrow transplantation (BMT) for donor cells engraftment into the bone marrow environment and lymphoid tissue compartment across MHC barrier under short-term αβ-TCRmAb/CsA protocols. Materials and Methods: Forty-eight BMT were performed between ACI (RT1a) donors and LEW (RT1l) recipients.
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