Abstract
Background: Donor bone marrow transplantation (BMT) is considered to promote chimerism and organ tolerance. The aim of this study was to introduce immunotherapy with adoptive transfer of donor-specific chimeric cells to support graft acceptance and function in composite tissue allograft transplants. Methods: Ten transplantations of hematopoietic stem cells (HSC) across MHC barrier were performed using LBN (RT1n) and ACI (RT1a) donor rats (n = 5/each) to Lewis (RT1l) recipients. Experimental groups were studied under 7 days of αβ-TCRmAb/CsA protocol.
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