Abstract
In present work, new tetra-dentate ligand, titled 3,5-bis ((E)-5-Bromo-2-hydroxy benzylidene amino) benzoic acid (H3L), was prepared via an acid-catalyzed condensation process. New four metallic ligand complexes with Co(II), Ni(II), Cu(II) and Zn(II) ions, were also prepared from the refluxing of equivalent moles. Ligand's structure and its complexes; were confirmed by numerous characterization methods, including Ultraviolet-Visible, Infrared, Mass Spectrometer, 1H and 13C Nuclear Magnetic Resonance spectra, atomic absorption, magnetic moments, and molar conductivity measurements. The results of the spectroscopic analyzes proved that the prepared ligand acts as tetradentate bi-ionic ligand and it was bonded to the metal ions by two nitrogen atoms of the two azomethine groups and by two oxygen atoms of the two phenolic hydroxyl groups after losing their two protons. Octahedral structure proposed to all prepared complexes. The (anti-bacterial) and (anti-fungal) activities of these compound were screened against (E. coli, S. aureus, Klebsiella spp., S. epidermidis,), and (Candida albicans). The results indicated that these compounds have moderated inhibition behavior. The activity of the prepared compounds against Acetyl Choline Esterase Enzyme (AChE) have also studied and the obtained data indicated the presence of different inhibition behavior.
Highlights
IntroductionThe ease of preparation of organic Schiff bases compounds (from the condensation among an aldehydes and a primary amines), and its ability to form stable coordination complexes (via chelation by azomethine group) with a different and huge number of metal ions in diverse oxidation states and coordination numbers, motivated the researchers in different scientific fields to prepare and use these privileged organic compounds 1-6
The ease of preparation of organic Schiff bases compounds, and its ability to form stable coordination complexes with a different and huge number of metal ions in diverse oxidation states and coordination numbers, motivated the researchers in different scientific fields to prepare and use these privileged organic compounds 1-6
The poly or tetra-dentate Schiff base ligands with N2O2 coordination system and their metallic complexes have been gained the attention of scientific researchers due to excellent complexation ability, so it is used in analytical field to remove of some heavy pollutant metals
Summary
The ease of preparation of organic Schiff bases compounds (from the condensation among an aldehydes and a primary amines), and its ability to form stable coordination complexes (via chelation by azomethine group) with a different and huge number of metal ions in diverse oxidation states and coordination numbers, motivated the researchers in different scientific fields to prepare and use these privileged organic compounds 1-6. The poly or tetra-dentate Schiff base ligands with N2O2 coordination system and their metallic complexes have been gained the attention of scientific researchers due to excellent complexation ability, so it is used in analytical field to remove of some heavy pollutant metals In catalytic reactions the tetra-dentate Schiff base ligands have been used for controlling the radical polymerization, as catalysts for oxidation of phenol, a good catalytic for increasing the chain length of the imine. Some chelated complexes N2O2 Schiff base ligands reveals its coefficients as photoactive materials due to their high intensity of fluorescence 27
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