New Poly Vinyl Chloride Ion Selective Electrode for Potentiometric Analysis of Propranolol in its Pharmaceutical Formulations and Human Fluids

Abstract

New, simple, sensitive and rapid method for the determination of propranolol in the pharmaceutical preparations and human fluids. The Buildup and electrochemical response characteristics of a poly vinyl chloride (PVC) selective membrane electrode for the determination of propranolol (POP) are described in this research. The proposed electrodes was composed of propranolol-bromophenol blue as ion-exchanger and Di-butyl phthalate (DBPH) (electrode A), tris (2-ethylhexyl) phosphate (TEHP) (electrode B), and ortho-nitrophenyloctylether (ONPOE) (electrode C), as plasticizers. The slope was 50.94, 57.77, and 49.75 mV/decade for electrode A, B and C. the linear range was 5 ×10-5 – 1×10-2, 1×10-4 – 1×10-2, and 5×10-5 – 1×10-2 M, a detection limit of 4.2×10-5, 8.9×10-5, and 4.8×10-5 M, lifetime of 21, 42, and 1-day, respectively. Electrode B gives the best results, so the application of pharmaceutical and human fluids was based upon this electrode, the recovery percentage was 103, 101, 102.5, and 104 for POP tablet 10mg, tablet 40mg, urine and plasma by standard addition method, respectively.