New Mn(II)-coordination polymer based on flexible benzimidazol ligand: crystal structure and treatment on osteosarcoma

Abstract

In this study, a Mn(II)-based coordination polymer with the chemical composition of {[Mn(L)(TBTA)(H 2 O) 2 ]·H 2 O} n ( 1 ) was prepared by reacting Mn(OAc) 2 ·2H 2 O with the flexible ligand 1,4-bis(5,6-dimethylbenzimidazol-1-yl)-2-butylene in the aid of the carboxylic acid ligand tetrabromoterephthalic acid (H 2 TBTA) through the mixed-ligand method. Its application values on osteosarcoma were measured, and the internal principle was discussed simultaneously. The inhibitory activity of the new compound on the multiplication of osteosarcoma cells was evaluated using the Cell Counting Kit-8 detection kit. The facilitation of the LKB1-mTORC1 signaling pathway was estimated via real-time RT-PCR.