Abstract
Global Journal of Endocrinological Metabolism New Insights into Inflammation in Atherosclerosis Open or Close Michael AB Naafs* Naafs International Health Consultancy, Europe *Corresponding author: Michael AB Naafs, Dutch Internist Endocrinologist, Health Consultant at Naafs International Health Consultancy, Rhodoslaan, Oldenzaal, The Netherlands Submission: September 10, 2018; Published: September 19, 2018 DOI: 10.31031/GJEM.2018.02.000547 ISSN 2637-8019Volume2 Issue4
Highlights
Atherosclerosis is an inflammatory disease and a pivotal role for inflammation in the pathogenesis has been recognized in animal models and at the molecular level [1,2]
Explain how arterial inflammation develops into atherosclerosis are explored
IL-1-beta plays an important role in these pathways raising new interest in therapeutics as colchicine and niacin
Summary
Atherosclerosis is an inflammatory disease and a pivotal role for inflammation in the pathogenesis has been recognized in animal models and at the molecular level [1,2]. Whole exome and whole genome sequencing will come soon, showing new and old loci associated with atherosclerosis. This opens the way to new molecular targets in inflammatory pathways attractive for blocking atherosclerosis even in its early stages. A suite of trials are pursuing anti-inflammatory therapies in atherosclerosis In this mini-review recent developments in pathogenesis, pathophysiology, biomarkers and therapeutics are discussed. Atherosclerosis is a chronic inflammatory and immune disease involving multiple cell types, including monocytes, macrophages, T-lymphocytes, endothelial cells, smooth muscle cells and mast cells [7]. Copyright © All rights are reserved by Michael AB Naafs
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
