Abstract
The novel, chiral, host compounds 8 and 9 were derived from tartaric acid. Inclusion complexation with these host compounds permitted highly efficient resolution of some aliphatic alcohols (10−13). The symmetrical dimer host compound 8 is effective for optical resolution of alcohols 10, 12, and 13 by a combination of enantioselective inclusion complexation and distillation techniques. The unsymmetrical dimer host compound 9 is effective for optical resolution of cyanohydrin 11. The crystal structures of the inclusion complexes were analyzed by X-ray diffraction methods in order to elucidate the mechanism of the efficient chiral recognition in the inclusion crystals.
Published Version
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