Abstract

4-Oxoazetidin-2-yl benzoate was resolved efficiently by an inclusion complexation with a chiral host compound, ( R, R)-(−)- trans-4,5-bis(hydroxydiphenylmethyl)-1,4-dioxaspiro[4.5]decane. The phenyl substituent on the β-lactam ring was found to play an important role in an efficient chiral recognition in the inclusion crystals.

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