New analysis for itopride hydrochloride utilizing chemically modified carbon paste sensor in ganaton, garopride, bulk, human urine/plasma

Abstract

Constructed five novel selective, sensitive and accurate chemically modified carbon paste sensors for potentiometric determination of itopride. The ion-pair exchanger based on itopride phosphomolybdate (Ito-PM) (sensor 1), itopride phosphotungstate (Ito-PT) (sensor 2), mix of (Ito-PM) + (Ito-PT) (sensor 3), itopride tetraphenylborate (Ito-TPB) (sensor 4) and a mix of (Ito-PM) + (Ito-TPB) (sensor 5). The modified sensors developed with using 2-nitrophenyl phenyl ether (2-NPPE) the best mediator than others as tricresylphthalate (TCP) or dioctyl phthalate (DOP). All sensors exhibited a liner range from 1 × 10−6 to 1 × 10−2 M with Nernstian slopes ranged from 58.4 ± 0.5 to 60.5 ± 0.5 mV/decade over a pH 2.5–8.0 for all sensors. The sensors showed a good selectivity for the drug with respect to organic/inorganic cations, amino acids and sugars. The analytical methods of application applied using standard addition, the calibration curve and potentiometric titration methods in bulk solution, ganaton (50 mg) dosage form, and biological human fluids plasma/urine are taken from a healthy volunteer. In vitro dissolution rates were monitoring ganaton tablets. The best sensitivity sensors (3&5) useful for analytical applications in different states. The results confirmed excellent, satisfactory and validated recovery with no significant difference regarding for accuracy and precision comparable to the British Pharmacopoeia with those obtained. Statistical studying between the results from the proposed method and the results from the reference methods showed no significant difference.