Chemically Modified Carbon Sensors Mixed or Single for the Determination of Cardiovascular Drug Nafronyl Oxalate in Bulk, Praxilene and Human Fluids

Amal F Khorshid

doi:10.4172/2155-6210.1000153

Abstract

Three novel chemically modified Carbon Paste Sensors (CMCPs) were proposed for the determination of nafronyl potentiometric in bulk, pharmaceutical dosage form; human plasma/urine. The sensors were based on an ion-pair associates of nafronyl silicotungstic acid (Nf-St) (sensor 1), nafronyl silicomolybdic acid (Nf-SM) (sensor 2), a mixture of (Nf-St)+(Nf-SM) (sensor 3). The modified sensors showed Nernstian slopes ranging from 58.5 ± 0.5-60.7 ± 0.5 mV over the concentration ranged from 1.0x10-7-1.0x10-2 M and pH 2.0-6.0 with detection limit 0.1 nM. The sensors exhibited good selectivity for nafronyl with respect to inorganic/organic cations, sugars and amino acids. The calibration curve, standard addition and potentiometric titration methods were applied for the determination of nafronyl ion in its bulk powder, pharmaceutical dosage form, and human fluids plasma/urine taken from a healthy volunteer and for the monitoring Praxilene tablets in vitro dissolution rates. Sensor 3 had been the best sensitivity so was successfully used for the determination the solubility products of ion-pair associates. The results were excellent and satisfactory recovery comparable to those obtained with the British Pharmacopoeia.

Highlights

Naftidrofuryl oxalate (Nf-(COOH)2)is known as nafronyl oxalate, which is an alpha-(1-Naphthylmethyl)-2-tetrahydrofuranpropionic acid diethylaminoethyl ester oxalate
The results presented in the paper show that the sensor constructed for naftidrofuryl ion has a wide concentration range, low limit of detection, good Nernstain slope, and
Plasma was used within 24 h and provided by VACSERA (Giza, Egypt) while urine samples were obtained from healthy volunteers

Summary

Introduction

Naftidrofuryl oxalate (Nf-(COOH)2)is known as nafronyl oxalate, which is an alpha-(1-Naphthylmethyl)-2-tetrahydrofuranpropionic acid diethylaminoethyl ester oxalate. The empirical formula of nafronyl oxalate is (C26H35NO7) and its molecular weight is Naftidrofuryl oxalate (3200-06-4) belongs to a group of medicines called vasodilator in the treatment of peripheral and cerebral vascular disorders [1,2]. The spectrophotometric methods of drug analysis usually suffer from poor selectivity. Others include a flow injection analysis with fluorescence optosensor [16]. Many of these methods involve derivatization reactions, several time-consuming manipulations, extraction steps, that are liable to various interferences, and are not applicable to colored and turbid solutions either. No methods in the literature for determination [Nf] by Chemical Modified Carbon Paste Sensor (CMCPs)

Methods

Findings

Discussion

Conclusion