Abstract
Background: Noise has become inexorable stress due to the increase in urbanization, automobile usage, and lifestyle modification.Aim: The study aims to investigate the effect of chronic noise stress on hippocampal morphology and the neuroprotective effect of Glycyrrhiza glabra (GG) on stress-induced male Wistar albino rats. Methods: Adult albino rats were randomly divided into four groups. Each group contained six animals. Rats exposed to chronic noise stress (100 dB/4 h – 30Days), Noise + GG (150 mg/kg Bw/Oral), and GG alone were compared with control animal and assessed for behaviour using the hole-board test, marble burying test, the morphology of hippocampus by histology, DNA fragmentation and assessed the Phytochemical constitutes in GG. Results: The rats exposed to chronic noise stress showed significance (p<0.05) of behavioral alterations such as increased fear and anxiety, obsessive-compulsive behaviour, enlarged lateral ventricle, and reduced hippocampal volume. Conclusion: The results reported that chronic noise stress affects the neurobehavioral due to reduced hippocampal volume.
Highlights
All living creatures depend on their environments for energy and materials that help in sustaining life
2015 reported that, phytochemical screening of the ethanolic extract of Glycyrrhiza glabra root revealed the presence of alkaloids, glycosides, carbohydrates, starches, phenolic compounds, flavonoids, proteins, pectin, mucilage, saponins, lipids, tannins, sterols and steroid(16).Chronic stress shown reduction of the whole brain (Figure 1) and Hippocampal weight (Figure 2) of the animals when compared to the control animals and Noise + GG shown statistically increased whole brain weight and hippocampal weight when compared to the chronic noise group animals.Whole brain weight and hippocampal weight was reduced in chronic noise induced animals
Brain cells are at particular risk of being damaged by free radicals because the brain has a high oxygen turnover and neuronal membranes in central nervous system (CNS) are rich in polyunsaturated fatty acids, which are the potential targets for lipid peroxidation
Summary
All living creatures depend on their environments for energy and materials that help in sustaining life. Enormous studies have shown that noise above 90dB increases the stress hormones and can cause significant impact on human health. Noise has become inexorable stress due to the increase in urbanization, automobile usage, and lifestyle modification.Aim: The study aims to investigate the effect of chronic noise stress on hippocampal morphology and the neuroprotective effect of Glycyrrhiza glabra (GG) on stress-induced male Wistar albino rats. Rats exposed to chronic noise stress (100 dB/4 h – 30Days), Noise + GG (150 mg/kg Bw/Oral), and GG alone were compared with control animal and assessed for behaviour using the hole-board test, marble burying test, the morphology of hippocampus by histology, DNA fragmentation and assessed the Phytochemical constitutes in GG. Results: The rats exposed to chronic noise stress showed significance (p
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