Abstract
Objective: The study aims to investigate the effect of chronic noise stress on hippocampal morphology and its functions in male Wistar albino rats.
 Methods: Adult albino rats were randomly divided into two groups. Each group contained six animals. Rats exposed to chronic noise stress (100 dB/4 h–30 days) were compared with control animal and assessed for behavior using hole-board test, marble burying test, and morphology of hippocampus by histology.
 Results: The rats exposed to chronic noise stress showed significance (P < 0.05) of behavioral alterations such as increased fear and anxiety, obsessive-compulsive behavior, enlarged lateral ventricle, and reduced hippocampal volume.
 Conclusion: The results reported that chronic noise stress affects neurobehavioral due to reduced hippocampal volume.
Highlights
All living creatures depend on their environments for energy and materials that help in sustaining life
Chronic stress induces reduction of the whole brain (Fig. 1) and hippocampal weight (Fig. 2) of the animals significantly when compared to the control animals
Sections obtained from the brain of chronic noise stress animals exhibited shrinking and enlargement of lateral ventricle when compared to the control brain (Figs. 5 and 6)
Summary
All living creatures depend on their environments for energy and materials that help in sustaining life. The environment sustains human life, it can cause diseases [1]. The health impacts caused by excessive environmental noise are a growing concern. Enormous studies have shown that noise above 90 dB increases the stress hormones and can cause a significant impact on human health. The brain is the target organ for corticosteroids [3] and the hippocampus is vulnerable to a number of insults and is prone to excitotoxic activity [4]. Receptors for glucocorticoids are found in the hippocampus, amygdala and frontal cortex, these three brain regions are involved in-memory processing, and emotional regulation [3,5]. It was planned to study the effect of chronic noise on hippocampal functions in a noise-induced animal model
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