Abstract
The article presents an overview of domestic and international research on the feasibility and effectiveness of using a strategy of combining several drugs with fixed doses in one pill - a polypill - in patients with cardiovascular diseases, in particular after an acute coronary syndrome, with the aim of secondary prevention of repeated adverse events .
 The NEPTUNO study showed that the use of a cardiovascular combination drug containing acetylsalicylic acid, ramipril, atorvastatin (CNIC-Polypill) was associated with a significant reduction in the rate of recurrence of major adverse cardiovascular events, along with a delay in time to event, in in a large sample of real patients with a history of atherosclerotic cardiovascular disease in comparison with three different control groups of active treatment (monocomponent, equipotent and other therapy). In addition, the use of CNIC-Polypill provided better blood pressure and lipid control, as well as longer duration of continuous medication. The results of the NEPTUNO study confirmed the usefulness of this strategy for the secondary prevention of cardiovascular diseases.
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